Baclofen is an FDA-approved musculoskeletal relaxer used to treat spasms and stiffness caused by multiple sclerosis and spinal cord diseases. Introduced originally in 1960, Baclofen was made to treat epilepsy. However, the outcome did not satisfy the medical experts and they stopped the use of the medication for epileptic seizures. Later, the researchers discovered that baclofen is very effective in the treatment of muscle spasticity.
If you suffer from muscle pain and stiffness, your doctor might prescribe you this drug. Now you can easily order Baclofen 20 Mg online on Shopemed.
The FDA has approved Baclofen for managing reversible spasticity, specifically, for relieving flexor spasms, clonus, concomitant pain, common sequelae of spinal cord lesions, and multiple sclerosis. Apart from the licensed uses, Baclofen also has several off-label medical uses. Though the FDA does not yet accept these uses, the ongoing research about Baclofen’s potential has helped discover new hope. Here are the examples of label uses ;
Baclofen primarily works by affecting the nervous system, specifically by activating GABA receptors in the brain and spinal cord.
Here's how baclofen works for muscle spasticity:
GABA Receptor Activation:
Baclofen binds to and activates GABA-B (gamma-aminobutyric acid type B) receptors in the central nervous system. GABA is an inhibitory neurotransmitter that helps regulate the activity of neurons. When GABA binds to its receptors, it prevents the rapid firing of neurons. This event leads to a reduction in nerve signaling and muscle activity. Hence, the involuntary muscle contractions stop. Lowering Nervous Excitability: By activating GABA-B receptors, baclofen reduces the excitability of neurons in the brain and spinal cord. This dampens the transmission of signals along nerve pathways involved in muscle spasticity, leading to the relaxation of muscles and a decrease in spasticity.
Inhibition of Reflex Pathways: Baclofen stops the transmission of signals along reflex pathways in the spinal cord. These reflex pathways are involved in the initiation and maintenance of muscle spasticity. Baclofen strongly contributes to reducing reflexes and muscle contractions due to spasticity by blocking these pathways. Changing Neurotransmitter Release: Baclofen may also be responsible for modulating the release of other neurotransmitters, such as glutamate and noradrenaline. These neurotransmitters regulate muscle tone and spasticity. By changing the balance of neurotransmitters in the central nervous system, baclofen helps to restore normal muscle tone and reduce spasticity.
In addition, baclofen's mechanism of action involves modulating neurotransmitter activity in the central nervous system, leading to a reduction in muscle spasticity and an improvement in muscle function for individuals with conditions such as multiple sclerosis, spinal cord injury, cerebral palsy, or other neurological disorders associated with spasticity.
Alcoholic liver disease is the most common repercussion of drinking excessive alcohol. It is also one of the most common reasons behind alcohol-related death in the world. But why does the liver get damaged by alcohol consumption?
The liver is the strongest organ in the body. It filters everything you eat and drink so that your body remains toxin-free. Since the liver is the principal site of ethanol metabolism, heavy drinking causes harm to the tissue. Usually, the liver re-generates new cells and keeps functioning. However, due to alcohol processing, liver cells start to die. Liver issues like hepatitis might start and end up escalating to cirrhosis.
AUD or Alcohol Use Disorder is a condition marked by your inability to stop drinking alcohol. In this condition, you become dependent on alcohol and without it, you will display withdrawal symptoms. When you suddenly stop drinking after a long period of heavy drinking, you will develop symptoms like:
One of the most striking off-label uses of Baclofen is in the treatment of alcohol use disorder. Baclofen helps minimize the craving and contributes effectively to maintaining abstinence.
Trigeminal neuralgia is an extreme form of pain that hurts like a sharp, shooting pain. This pain usually hurts on the one side of the face. This chronic pain condition can be long-lasting. From subtle touch to light movement of the face: anything can trigger pain. Some common symptoms of this condition are:
Baclofen decreases substance P in the spinal cord to relieve pain. When treating TGN, the initial oral dosage of baclofen is 15 mg, given in three separate doses. This is followed by a gradual titration to a maintenance dose of 50–60 mg daily.
A baclofen pump, also known as an intrathecal baclofen pump, is a medical device used to deliver baclofen directly into the spinal fluid (intrathecal space) to manage severe spasticity. The pump is implanted surgically under the skin of the abdomen, and a catheter is threaded into the spinal canal to deliver the medication. This technique is generally used when baclofen cannot be given orally or when the oral medication provokes too many side effects. Here's how a baclofen pump works:
The baclofen pump is implanted under the skin of the abdomen during a surgical procedure. The pump itself is a small device, similar in size to a hockey puck, that contains a reservoir filled with baclofen medication. The pump is connected to a catheter, which is inserted into the spinal canal.
The pump continuously delivers a controlled amount of baclofen directly into the spinal fluid. Bypassing the digestive system and delivering the medication directly to the spinal cord, the pump allows for more specific and effective treatment of severe spasticity and you don’t have to suffer the side effects.
One of the best advantages of using a baclofen pump is you have the perfect control The amount of baclofen delivered by the pump can be adjusted by a healthcare provider based on the needs of patients. This allows you to have precise control over the dosage. It lets you achieve optimal pain relief of spasticity while minimizing side effects.
After using it, you have to fill the reservoir periodically with baclofen solution. This is usually done through a small port on the surface of the skin using a needle and syringe. The frequency of refills depends on the dosage and the size of the reservoir.
Baclofen pumps are typically recommended for patients with severe spasticity who cannot respond adequately to oral medications or when oral medications cause intolerable side effects. This pump is especially helpful with conditions such as spinal cord injury, multiple sclerosis, cerebral palsy, or other neurological disorders associated with severe and disabling spasticity.
You can easily order Baclofen online from the reliable US-based digital drugstore Shopemed. Shopemed offers Zero shipping charges on orders and will ship your medications overnight during an emergency. At the same time, they deliver medications right to doorstep delivery wherever in the US you may be! Place your Baclofen 20mg order online from the comfort of your home!
The dosage of this medication entirely depends on the condition of the patient. Baclofen is a prescription medication the dosage of which must be decided by the physician. Follow the label's instructions and ask your doctor's advice when necessary.
Your dosage of medication is determined by the medication's potency. Additionally, the medication you take for a medical condition determines how many dosages you take daily, how long you take it for, and how much time you allow between doses. The standard dosages of this medication are listed in the information that follows.
On Shopemed Baclofen is available in the form of a tablet. This oral tablet is to be taken by mouth with a glass of water. When you take this drug, make sure to take it as a whole. You should not break or chew the tablet. Breaking or dry chewing the tablet will release all the medications together and your body might face trouble processing the medication. This might lead to adverse effects.
If suggested, only then should you take half a tablet and preserve the other half properly. You can take this medication before or after taking food. If it upsets your stomach, do not take it without a meal. If you miss a dose, take the dose as soon as possible. If you remember your missed dosage just before your next dose, take only one and stay away from double dosing. You should store this medication properly, away from sunlight and moist place.
Adults and kids who are 12 years of age and up—Initially, three times a day for five milligrams.
On the other hand, the daily dose is often limited to 80 milligrams (mg) (20 mg four times a day).
Children under twelve: Your doctor must determine the use and dosage.
Adults and children twelve years of age and up: Initially, three times a day for three days, five milliliters (mL). Depending on your needs and tolerance, your doctor may raise your dosage by 5 mL every three days. On the other hand, the daily dose is often limited to 80 milligrams (mg) (20 mg four times a day).
Children under twelve: Your doctor must determine the use and dosage.
Adults and teenagers– treatment may be started with 5 milligrams (mg) 3 times a day. Your doctor might increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose should not exceed 80 mg per day.
Children—Use and dose must be determined by your doctor.
When your doctor prescribes you baclofen for muscle spasms due to multiple sclerosis or other muscle injury, you must check if you have any of the following conditions.
If any of these conditions resonate with you, do not take Baclofen without disclosing your thorough medical history to your doctor or healthcare provider.
As CNS depressants, alcohol, and baclofen both work by interacting with neurotransmitters, especially GABA, to produce a relaxed feeling. So when you combine the two, you might experience an extreme level of drowsiness, dizziness, and confusion. This also might lead to overdose. If you feel sick after combining the two, call for emergency help immediately.
1. How does baclofen work for muscle pain?
Baclofen impacts the spinal cord nerves and reduces the number and extremity of muscle spasms caused by multiple sclerosis or spinal cord conditions. It also provides relief from pain and improves muscle movement.
2. What is baclofen used for?
Baclofen is a skeletal muscle relaxer that treats muscle stiffness, and muscle pain that occur due to multiple sclerosis, Spinal cord injury, and other trauma to spinal nerves. Off-label, Baclofen is used to treat alcoholic liver disorder, decreasing alcohol craving and trigeminal neuralgia. The FDA does not yet approve these uses.
3. Where can I buy Baclofen?
You can buy Baclofen online from Shopemed. Shopemed is a renowned name in healthcare for its prompt delivery and free shipping all over the US with every order. To make their service more customer-friendly, they offer express delivery and even, emergency overnight shipping when needed.
4. Which class of drug is baclofen?
Baclofen helps treat muscle spasticity and stiffness. This medication belongs to the group called skeletal muscle relaxants.
5. Why Baclofen pump is used?
The Baclofen pump helps to inject the medication directly into the spinal fluid. You can precisely control how much medication is to be administered. The Baclofen pump is used for patients who cannot orally take the medication or suffer too many side effects.
6. Is baclofen addictve ?
Baclofen is a muscle relaxer that belongs to the musculoskeletal relaxant groups. Taken in the right dosage, based on the severity of the condition, weight, and medical history, Baclofen helps your muscle spasticity soothe.
But if you take this medication in higher doses, and in increased frequency you might become addicted to it. If this happens, you need to talk to your doctor about the addiction.
7. How should I take baclofen?
Baclofen tablets are prescribed by your doctor. The oral tablets are taken by mouth with a glass of water. The tablets are not to be broken, chewed, or crushed. You must follow the prescribed dosage. The baclofen pump is used according to the doctor’s suggestion and the process must be handled by a medical professional.
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